SCI
13 September 2024
Targeting the tumour vasculature: from vessel destruction to promotion
（Nat Rev Cancer; IF:72.5）
Guelfi S, Hodivala-Dilke K, Bergers G: Targeting the tumour vasculature: from vessel destruction to promotion. Nat Rev Cancer 2024.
Correspondence to: k.hodivala-dilke@qmul.ac.uk; gabriele.bergers@kuleuven.be
As angiogenesis was recognized as a core hallmark of cancer growth and survival, several strategies have been implemented to target the tumour vasculature. Yet to date, attempts have rarely been so diverse, ranging from vessel growth inhibition and destruction to vessel normalization, reprogramming and vessel growth promotion. Some of these strategies, combined with standard of care, have translated into improved cancer therapies, but their successes are constrained to certain cancer types. This Review provides an overview of these vascular targeting approaches and puts them into context based on our subsequent improved understanding of the tumour vasculature as an integral part of the tumour microenvironment with which it is functionally interlinked. This new knowledge has already led to dual targeting of the vascular and immune cell compartments and sets the scene for future investigations of possible alternative approaches that consider the vascular link with other tumour microenvironment components for improved cancer therapy.
随着血管生成被认为是肿瘤生长和生存的核心标志，针对肿瘤血管的多种策略被实施。迄今为止，从抑制和破坏血管生长到血管正常化、重编程和促进血管生长的尝试越来越多样化。其中一些策略与标准治疗相结合，已转化为改进的癌症疗法，但它们的成功仅限于某些癌症类型。这篇综述提供了这些血管靶向方法的概述，并基于我们对肿瘤血管作为肿瘤微环境的一个组成部分的进一步理解，将它们放在功能上相互联系的背景下。本综述概述了这些血管靶向方法，并根据我们对肿瘤血管系统作为肿瘤微环境不可分割的功能性组成部分的理解加以分析。这一新知识已经导致了血管系统和免疫细胞成分的双重靶向，并为未来研究可能的替代方法奠定了基础，这些方法将考虑血管与其他肿瘤微环境组成部分的联系，以改进癌症治疗。
喜欢SCI天天读的理由
陪您一起学习SCI医学论文
每天5分钟，让自己的英语牛逼起来
特殊福利让您惊喜连连
W230N06
链接：https://pan.baidu.com/s/15ofB3gWW_u4im80Qg8htkg?pwd=wts7
提取码：wts7
